List of EM user’s publication
2025
Gary Jen-Wei Chen, Ming-Yun Chang, Xin-Peng Lin, Debapriya Kundu, Yu-Jen Chang, Yun-Ru Chen*. Tau destabilization in a familial deletion mutant K280 accelerates its fibrillization and enhances the seeding effect. Journal of Biological Chemistry. 301(4), 108312, 2025-04.
Allahyartorkaman M, Chan TH, Chen EH, Ng ST, Chen YA, Wen JK, Ho MR, Yen HY, Kuan YS, Kuo MH, Chen RP. Phosphorylation-Induced Self-Coacervation versus RNA-Assisted Complex Coacervation of Tau Proteins. Journal of the American Chemical Society. 147(12), 10172-10187, 2025-03-26.
Nai Yang Yeat, Li-Heng Liu, Yu-Hsuan Chang, Charles Pin-Kuang Lai, Ruey-Hwa Chen. Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies. Developmental Cell. 60(8), 1024-1038, 2025-04-21.
Hsu Chung-Yao, Tsai Po-Cheng, Lin Jung-Chen, Pai Chen-Hsueh, Teng Yun-Jui, Yao Bing-Yu, Fei Cheng-Yin, Shiau Gwo Harn Max, Lin Leon CW, Lo Sean, Yang Hung-Chih, Hu Che-Ming Jack. Polymerised superparamagnetic antigen presenting cell lymphocyte capture for enriching tumour reactive T-cells and neoantigen identification. Nature Communications. 16(1), 5088, 2025-06-02.
Lin YJ, Huang LT, Ke PY, (Chen GC)*. The deubiquitinase USP45 inhibits autophagy through actin regulation by Coronin 1B. Journal of Cell Biology. 224(5), e202407014, 2025-03.
Selvaraj SP, Chang JC, Raja K, Zsu JT, Hazam PK, Lin WC, Huang JR*, Li TL*, Chen JY*. Novel self-assembled antimicrobial peptide Pardaxin hydrogel as a functional biomaterial for food packaging and preservation. Chemical Engineering Journal. 525, 170727, 2025-11-10.
Negi Abhishek, Kuo Chia-Wei, Hazam Prakash Kishore, Yeh Jih-Chao, Lin Wen-Chun, Lou Yuan-Chao, Yu Chao-Yuan, Yu Tsai-Luen, Lu Tsai-Ming, (Chen Jyh-Yih*). Disruption of MRSA Biofilm and Virulence by Deep-Sea Probiotics: Impacts on Energy metabolism and Host Antimicrobial Peptides. Probiotics and Antimicrobial Proteins. 17(4), 2394-2416, 2025-04-14.
Lin Wen-Chun, You Ming-Feng, Chen Yun-Ru, (Chen Jyh-Yih*). Optimized TPL6 Peptide Gel Exhibits Broad-Spectrum Antimicrobial Activity and Effectively Treats Drug-Resistant Wound Infections in Diabetic Mice. Advanced Healthcare Materials. 14(7), e2403211, 2025-03.
Negi Abhishek, Yadav Bal Govind, Aakanksha, Kuo Chia-Wei, Hazam Prakash Kishore, Lin Wen-Chun, Teh Ooi-Kock, (Chen Jyh-Yih*). A Deep-Sea probiotic platform: Dual-function biopreservation for aquaculture immunomodulation and meat shelf-life extension. Innovative Food Science & Emerging Technologies. 104, 104107, 2025-08.
Chih-Ming Ho, Ting-Lin Yen, Tzu-Hao Chang, Shih-Hung Huang*. Extracellular-Vesicle-Associated UBE2NL and HIST2H3PS2 Promote Tumor Aggressiveness and Metastasis in Gynecologic Cancer. International Journal of Molecular Sciences. 26(10), 4833, 2025-05.
Wu WK, Lo YL, Chiu JY, Hsu CL, Lo IH, Panyod S, Liao YC, Chiu THT, Yang YT, Kuo HC, Zou HB, Chen YH, Chuang HL, Yen JJY, Wang JT, Chiu HM, Hsu CC, Kuo CH, Sheen LY, Kao HL, Wu MS. Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition. Gut Microbes. 17(1), 2446374, 2025-01.
Chen Che-Chih, Xie Qiao-Yi, Chuang Po-Shun, Darnajoux Romain, Chien Yi-Ying, Wang Wen-Hong, Tian Xuejiao, Tu Chiao-Hui, Chen Bi-Chang, Tang Sen-Ling, (Chen Ko-Hsuan*). A thallus-forming N-fixing fungus-cyanobacterium symbiosis from subtropical forests. Science Advances. 11(7), adt4093, 2025-02.
Wahyuningtyas D, Yu Yoyo CT, Hsieh CY, Huang YA, He RY, Teng TH, Chen BPW, Huang JR, Wu David, Huang JJT*. Self-Assembled Hydrogel from Pyrene-Modified Peptide as 3D Matrices for Neuronal Cells. ACS Applied Bio Materials. 9(2), 800–812, 2025-12-30.
Narathip Naradun, Piyasiri Chueakwon, Anyanee Kamkaew, Kai-Yu Hsu, Man Nee Lee, Kantapat Chansaenpak, Yane-Shih Wang, Rung-Yi Lai*. Ferritin Fused with MiniSOG for In Vitro Photodynamic Therapy. ACS Applied Bio Materials. 8(5), 3909-3919, 2025-04-22.
Adilet Beishenaliev, Yean Leng Loke, Chung-Yin Lin, Sook Jing Goh, Jaya Seema, Yuhan Huang, Xin Yun Lim, Yu-Wen Chen, Bey Fen Leo, Chia-Yu Chang, Lip Yong Chung, Chia-Ching Chang, Yin Yin Teo*, Dennis W. Hwang*, Lik Voon Kiew*. Ultrasmall Gold Nanoparticles as “Three-in-One” Enzyme-Mimicking Nanocatalysts for Combined Sonodynamic/Catalytic Therapy in Breast Cancer. ACS Applied Materials & Interfaces. 17(50), 67529-67542, 2025-12.
2024
Hsu Po-Hsien, Hazam Prakash Kishore, Huang Yi-Ping, Yeh Jih-Chao, Chen Yun-Ru, Li Chao-Chin, Chang Chi-Fon, Liou Je-Wen, (Chen Jyh-Yih)*. Sequential rearrangement and stereochemical reorganization to design an antimicrobial peptide with enhanced stability. Biomedicine & Pharmacotherapy. 170, 116088, 2024-01.
Hsu Po-Hsien, Hazam Prakash Kishore, Huang Yi-Ping, Yeh Jih-Chao, Chen Yun-Ru, Li Chao-Chin, Chang Chi-Fon, Liou Je-Wen, (Chen Jyh-Yih)*. Optimization of sequence and chiral content enhances therapeutic potential of tilapia piscidin peptides. European Journal of Medicinal Chemistry. 265, 116083, 2023-12-23.
Yu-Jen Chang, Kai-Tai Lin, Orion Shih, Chi-Hua Yang, Ching-Yu Chuang, Ming-Han Fang, Wei-Bin Lai, Yi-Chung Lee, Hung-Chih Kuo, Shang-Cheng Hung, Chi-Kuang Yao, U-Ser Jeng, (Yun-Ru Chen)*. Sulfated disaccharide protects membrane and DNA damages from arginine-rich dipeptide repeats in ALS. Science Advances. 10(8), eadj0347, 2024-02-23.
Tien-Ying Tsai, Wei-Ting Jhang, Hung-Kai Hsu, Yi-Tsu Chan, Chi-Fon Chang, (Yun-Ru Chen)*. Amyloid Modifier SERF1a Accelerates Alzheimers Amyloid-β Fibrillization and Exacerbates the Cytotoxicity. ACS Chemical Neuroscience. 15(3), 479-490, 2024-01.
Yuh-Charn Lin, Ya-Jen Chang, Shiang-Shin Gau, Chun-Min Lo, Ruey-Bing Yang. SCUBE2 regulates adherens junction dynamics and vascular barrier function during inflammation. Cardiovascular Research. 120(13), 1636-1651, 2024-06-13.
Lee CH, Saw JE, Chen EH, Wang CH, Uchihashi T, (Chen RP)*. The positively charged cluster in the N-terminal d
isordered region may affect prion protein misfolding: Cryo-EM structure of hamster PrP(23-144) fibrils. Journal of Molecular Biology. 436(11), 168576, 2024-06.
Songqiang Tang, Chun-Hsiang Huang, Tzu-Ping Ko, Kuan-Fu Lin, Yuan-Chih Chang, Po-Yen Lin, Liuchang Sun, Chin-Yu Chen. Dual dimeric interactions in the nucleic acid-binding protein Sac10b lead to multiple bridging of double-stranded DNA. Heliyon. 10(11), e31630, 2024-06-15.
Hao-Yu Chuang, Ruei-Yu He, Yung-An Huang, Wan-Ting Hsu, Ya-Jen Cheng, Zheng-Rong Guo, Niaz Wali, Ing-Shouh Hwang, Jiun-Jie Shie, Joseph Jen-Tse Huang. Engineered droplet-forming peptide as photocontrollable phase modulator for fused in sarcoma protein. Nature Communications. 15(1), 5686-5698, 2024-07-05.
Lin Chi-Long, Fang Zih-Syun, Hsu Chung-Yao, Liu Yu-Han, Lin Jung-Chen, Yao Bing-Yu, Li Fu-An, Yen Shin-Chwen Bruce, Chang Yuan-Chih, Hu Che-Ming J*. Rapid plasma membrane isolation via intracellular polymerization-mediated biomolecular confinement. Acta Biomaterialia. 173, 325-335, 2024-01-01.
Tsou JC, Tsou CJ, Wang CH, Ko AA, Wang YH, Liang HH, Sun JC, Huang KF, Ko TP, Lin SY, (Wang YS)*. Site-Specific Histidine Aza-Michael Addition in Proteins Enabled by a Ferritin-Based Metalloenzyme. Journal of the American Chemical Society. 146(49), 33309-33315, 2024-12.
Chao-Yu Yang, Yi-Chun Tseng, Yi-Fan Tu, Bai-Jiun Kuo, Li-Chung Hsu, Chia-I Lien, You-Sheng Lin, Yin-Ting Wang, Yen-Chen Lu, Tsung-Wei Su, Yu-Chih Lo*, (Su-Chang Lin)*. Reverse Hierarchical DED Assembly in the cFLIP-Procaspase-8 and cFLIP-Procaspase-8-FADD Complexes. Nature Communications. 15(1), 8974, 2024-10.
Chao-Yu Yang, Chia-I Lien, Yi-Chun Tseng, Yi-Fan Tu, Arkadiusz W. Kulczyk, Yen-Chen Lu, Yin-Ting Wang, Tsung-Wei Su, Li-Chung Hsu*, Yu-Chih Lo*, (Su-Chang Lin)*. Deciphering DED Assembly Mechanisms in FADD-Procaspase-8-cFLIP Complexes Regulating Apoptosis. Nature Communications. 15(1), 3791-3809, 2024-05.
Xiaorui Chen, Arpita Mohapatra, Hong Thuy Vy Nguyen, Lisa Schimanski, Tiong Kit Tan, Pramila Rijal, Cheng-Pin Chen, Shu-Hsing Cheng, Wen-Hsin Lee, Yu-Chi Chou, Alain R. Townsend, Che Ma, Kuan-Ying A. Huang. The presence of broadly neutralizing anti-SARS-CoV-2 RBD antibodies elicited by primary series and booster dose of COVID-19 vaccine. PLOS Pathogens. 20(6), e1012246, 2024-06-06.
Wu WK, Lo YL, Chiu JY, Hsu CL, Lo IH, Panyod S, Wu MS. Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition. Gut Microbes. 17(1), 2446374, 2025-01.
2023
Chou Pei-Hsuan, Hu Marian Y., Guh Ying-Jey, Wu Guan-Chung, Yang Shan-Hua, Tandon Kshitij, Shao Yi-Ta, Lin Li-Yih, Chen Chi, Tseng Kuang-Yu, Wang Min-Chen, Zhang Cheng-Mao, Han Bor-Cheng, Lin Ching-Chun, Tang Sen-Lin, Jeng Ming-Shiou, Chang Ching-Fong, (Tseng Yung-Che)*. Cellular mechanisms underlying extraordinary sulfide tolerance in a crustacean holobiont from hydrothermal vents. Proceedings of the Royal Society B: Biological Sciences. 290(1990), 20221973, 2023-01.
Magoling BJA, Wu AY, Chen YJ, Wong WW, Chuo ST, Huang HC, Sung YC, Hsieh HT, Huang P, Lee KZ, Huang KW, (Chen RH), Chen Y, Lai CP. Membrane Protein Modification Modulates Big and Small Extracellular Vesicle Biodistribution and Tumorigenic Potential in Breast Cancers in vivo. Advanced Materials. 35(13), 2208966, 2023-04.
Chu BK, Lin YS, Shen HC, (Chen RP)*. Cross-Seeding Assay in the Investigation of the Amyloid Core of Prion Fibrils. Methods in Molecular Biology. 2551, 633-647, 2023.
Huang KA*, Chen X, Mohapatra A, Nguyen HTV, Schimanski L, Tan TK, Rijal P, Vester SK, Hills RA, Howarth M, Keeffe JR, Cohen AA, Kakutani LM, Wu YM, Shahed-Al-Mahmud M, Chou YC, Bjorkman PJ, Townsend AR, (Ma C)*. Structural basis for a conserved neutralization epitope on the receptor-binding domain of SARS-CoV-2. Nature Communications. 14(1), 311, 2023-01.
Yang CF*, Liao CC, Hsu HW, Liang JJ, Chang CS, Ko HY, Chang RH, Tang WC, Chang MH, (Wang IH*), Lin YL*. Human ACE2 protein is a molecular switch controlling the mode of SARS-CoV-2 transmission. Journal of Biomedical Science. 30(1), 87, 2023-10-12.
Chen EH, Wang CH, Liao YT, Chan FY, Kanaoka Y, Uchihashi T, Kato K, Lai L, Chang YW, Ho MC*, (Chen RP)*. Visualizing the membrane disruption action of antimicrobial peptides by cryo-electron tomography. Nature Communications. 14(1), 5464, 2023-09.
Tien-Ying Tsai, Wei-Ting Jhang, Hung-Kai Hsu, Yi-Tsu Chan, Chi-Fon Chang, (Yun-Ru Chen)*. Amyloid Modifier SERF1a Accelerates Alzheimers Amyloid-β Fibrillization and Exacerbates the Cytotoxicity. ACS Chemical Neuroscience. 15(3), 479-490, 2024.
Lin CY, Chang YM, Tseng HY, Shih YL, Yeh HH, Liao YR, Tang HH, Hsu CL, Chen CC, Yan YT, Kao CF. Epigenetic regulator RNF20 underlies temporal hierarchy of gene expression to regulate postnatal cardiomyocyte polarization. Cell Reports. 42(11), 113416, 2023-11.
Lin Wen-Chun, Hsu Kai-Chen, You Ming-Feng, Lee Kuo-Hua, Chi Chau-Hwa, (Chen Jyh-Yih)*. Octanoic acid promotes clearance of antibiotic-tolerant cells and eradicates biofilms of Staphylococcus aureus isolated from recurrent bovine mastitis. Biofilm. 6, 100149, 2023-12.
Hsu Po-Hsien, Hazam Prakash Kishore, Huang Yi-Ping, Yeh Jih-Chao, Chen Yun-Ru, Li Chao-Chin, Chang Chi-Fon, Liou Je-Wen, (Chen Jyh-Yih)*. Optimization of sequence and chiral content enhances therapeutic potential of tilapia piscidin peptides. European Journal of Medicinal Chemistry. 265, 116083, 2023-12-23.
Yeh Jih-Chao, Hazam Prakash Kishore, Hsieh Chu-Yi, Hsu Po-Hsien, Lin Wen-Chun, Chen Yun-Ru, Li Chao-Chin, (Chen Jyh-Yih)*. Rational Design of Stapled Antimicrobial Peptides to Enhance Stability and In Vivo Potency against Polymicrobial Sepsis. Microbiology Spectrum. 11(2), e0385322, 2023-04.
Hazam PK, Cheng CC, Lin WC, Hsieh CY, Hsu PH, Chen YR, Li CC, Hsueh PR, (Chen JY)*. Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. European Journal of Medicinal Chemistry. 249, 115131, 2023-03.
Cheng YC, Hsieh ML, Lin CJ, Chang CMC, Huang CY, Puntney R, Moy AW, Ting CY, Chan DZH, Nicholson MW, Lin PJ, Chen CH, Kim GC, Zhang J, Coonen J, Basu P, Simmons HA, Liu YW, Hacker TA, Kamp TJ, Hsieh PCH*. Combined Treatment of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes and Endothelial Cells Regenerate the Infarcted Heart in Mice and Non-Human Primates. Circulation. 148(18), 1395-1409, 2023-10-31.
2022
Budi, Y. P., L. C. Lin, C. H. Chung, L. L. Chen and Y. F. Jiang (2022). "Three-Dimensional Investigations of Virus-Associated Structures in the Nuclei with White Spot Syndrome Virus (WSSV) Infection in Red Swamp Crayfish (Procambarus clarkii)." Animals (Basel) 12(13).
Chang, H. Y. and W. Y. Yang (2022). "Golgi quality control and autophagy." IUBMB Life 74(4): 361-370.
Chang, Y. W., Z. H. Song and C. C. Chen (2022). "FAK regulates cardiomyocyte mitochondrial fission and function through Drp1." Febs j 289(7): 1897-1910.
Chen, C. H., Y. H. Liu, A. Eskandari, J. Ghimire, L. C. Lin, Z. S. Fang, W. C. Wimley, J. P. Ulmschneider, K. Suntharalingam, C. J. Hu and M. B. Ulmschneider (2022). "Integrated Design of a Membrane-Lytic Peptide-Based Intravenous Nanotherapeutic Suppresses Triple-Negative Breast Cancer." Adv Sci (Weinh) 9(13): e2105506.
Cheng, Y. Y., Z. Gregorich, R. P. Prajnamitra, D. J. Lundy, T. Y. Ma, Y. H. Huang, Y. C. Lee, S. C. Ruan, J. H. Lin, P. J. Lin, C. W. Kuo, P. Chen, Y. T. Yan, R. Tian, T. J. Kamp and P. C. H. Hsieh (2022). "Metabolic Changes Associated With Cardiomyocyte Dedifferentiation Enable Adult Mammalian Cardiac Regeneration." Circulation 146(25): 1950-1967.
Chiang, W. C., Y. S. Fang, Y. S. Lye, T. Y. Weng, K. Ganesan, S. H. Huang, L. Y. Chang, S. C. Chou and Y. R. Chen (2022). "Hyperphosphorylation-Mimetic TDP-43 Drives Amyloid Formation and Possesses Neuronal Toxicity at the Oligomeric Stage." ACS Chem Neurosci 13(17): 2599-2612.
Chu, B. K., R. F. Tsai, C. L. Hung, Y. H. Kuo, E. H. Chen, Y. W. Chiang, S. I. Chan and R. P. Chen (2022). "Location of the cross-β structure in prion fibrils: A search by seeding and electron spin resonance spectroscopy." Protein Sci 31(6): e4326.
Hazam, P. K., C. C. Cheng, C. Y. Hsieh, W. C. Lin, P. H. Hsu, T. L. Chen, Y. T. Lee and J. Y. Chen (2022). "Development of Bactericidal Peptides against Multidrug-Resistant Acinetobacter baumannii with Enhanced Stability and Low Toxicity." Int J Mol Sci 23(4).
Huang, H. Y., H. Y. Liao, X. Chen, S. W. Wang, C. W. Cheng, M. Shahed-Al-Mahmud, Y. M. Liu, A. Mohapatra, T. H. Chen, J. M. Lo, Y. M. Wu, H. H. Ma, Y. H. Chang, H. Y. Tsai, Y. C. Chou, Y. P. Hsueh, C. Y. Tsai, P. Y. Huang, S. Y. Chang, T. L. Chao, H. C. Kao, Y. M. Tsai, Y. H. Chen, C. Y. Wu, J. T. Jan, T. R. Cheng, K. I. Lin, C. Ma and C. H. Wong (2022). "Vaccination with SARS-CoV-2 spike protein lacking glycan shields elicits enhanced protective responses in animal models." Sci Transl Med 14(639): eabm0899.
Lai, P. L., C. H. Ng, C. H. Wu, C. Y. Lai, S. C. Schuyler, V. Wang, H. Lin, Y. C. Lee, M. H. Chuang, C. H. Yang, W. J. Chen, H. C. Huang and J. Lu (2022). "Development of a Chemical Cocktail That Rescues Mouse Brain Demyelination in a Cuprizone-Induced Model." Cells 11(7).
Lee, H. W., Y. F. Jiang, H. W. Chang and I. C. Cheng (2022). "Foot-and-Mouth Disease Virus 3A Hijacks Sar1 and Sec12 for ER Remodeling in a COPII-Independent Manner." Viruses 14(4).
Lee, M. C., Y. H. Liao, S. H. Chen and Y. R. Chen (2022). "Amyloid-β40 E22K fibril in familial Alzheimer's disease is more thermostable and susceptible to seeding." IUBMB Life 74(8): 739-747.
Li, S. J., Y. H. Lin, C. H. Chiang, P. Y. Wang and C. Y. Chen (2022). "Early-onset dietary restriction maintains mitochondrial health, autophagy and ER function in the left ventricle during aging." J Nutr Biochem 101: 108944.
Lin, C. C., S. Y. Hoo, L. T. Ma, C. Lin, K. F. Huang, Y. N. Ho, C. H. Sun, H. J. Lee, P. Y. Chen, L. J. Shu, B. W. Wang, W. C. Hsu, T. P. Ko and Y. L. Yang (2022). "Integrated omics approach to unveil antifungal bacterial polyynes as acetyl-CoA acetyltransferase inhibitors." Commun Biol 5(1): 454.
Lin, C. J., Y. C. Cheng, H. C. Chen, Y. K. Chao, M. W. Nicholson, E. C. L. Yen, T. J. Kamp and P. C. H. Hsieh (2022). "Commensal gut microbiota-derived acetate and propionate enhance heart adaptation in response to cardiac pressure overload in mice." Theranostics 12(17): 7319-7334.
Tamang, H. K., R. B. Yang, Z. H. Song, S. C. Hsu, C. C. Peng, Y. C. Tung, B. H. Tzeng and C. C. Chen (2022). "Ca(v) 3.2 T-type calcium channel regulates mouse platelet activation and arterial thrombosis." J Thromb Haemost 20(8): 1887-1899.
Wu, J. L. and Y. R. Chen (2022). "Signal peptide stabilizes folding and inhibits misfolding of serum amyloid A." Protein Sci 31(12): e4485.
2021
Chan, M. H., C. N. Lu, Y. L. Chung, Y. C. Chang, C. H. Li, C. L. Chen, D. H. Wei and M. Hsiao (2021). "Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment." J Nanobiotechnology 19(1): 308.
Chen, C. Y., D. S. Lee, O. K. Choong, S. K. Chang, T. Hsu, M. W. Nicholson, L. W. Liu, P. J. Lin, S. C. Ruan, S. W. Lin, C. Y. Hu and P. C. H. Hsieh (2021). "Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy." Sci Rep 11(1): 2377.
Cheng, C. A., J. M. Luo, M. H. Chiang, K. Y. Fang, C. H. Li, C. W. Chen, Y. S. Wang and C. Y. Chang (2021). "Nervous Necrosis Virus Coat Protein Mediates Host Translation Shutoff through Nuclear Translocalization and Degradation of Polyadenylate Binding Protein." J Virol 95(17): e0236420.
Chien, H. M., R. Y. He, C. C. Lee, Y. A. Huang, I. J. Hung, K. T. Hou, J. C. Hsiao, P. C. Lu, D. Agnihotri, E. Hwang and J. J. Huang (2021). "Nanoscopic investigation of C9orf72 poly-GA oligomers on nuclear membrane disruption by a photoinducible platform." Commun Chem 4(1): 111.
Chou, H. Y., Y. T. Lee, Y. J. Lin, J. K. Wen, W. H. Peng, P. L. Hsieh, S. Y. Lin, C. C. Hung and G. C. Chen (2021). "PTPN9-mediated dephosphorylation of VTI1B promotes ATG16L1 precursor fusion and autophagosome formation." Autophagy 17(10): 2750-2765.
Fatiga, F. F., L. J. Wang, T. Hsu, J. I. Capuno and C. Y. Fu (2021). "Miro1 functions as an inhibitory regulator of MFN at elevated mitochondrial Ca(2+) levels." J Cell Biochem 122(12): 1848-1862.
Jiang, Y. F., P. H. Yu, Y. P. Budi, C. H. Chiu and C. Y. Fu (2021). "Dynamic changes in mitochondrial 3D structure during folliculogenesis and luteal formation in the goat large luteal cell lineage." Sci Rep 11(1): 15564.
Kuo, T. F., S. W. Hsu, S. H. Huang, C. L. Chang, C. S. Feng, M. G. Huang, T. Y. Chen, M. T. Yang, S. T. Jiang, T. N. Wen, C. Y. Yang, C. Y. Huang, S. H. Kao, K. C. Tsai, G. Yang and W. C. Yang (2021). "Pdia4 regulates β-cell pathogenesis in diabetes: molecular mechanism and targeted therapy." EMBO Mol Med 13(10): e11668.
Lin, J. C., C. Y. Hsu, J. Y. Chen, Z. S. Fang, H. W. Chen, B. Y. Yao, G. H. M. Shiau, J. S. Tsai, M. Gu, M. Jung, T. Y. Lee and C. J. Hu (2021). "Facile Transformation of Murine and Human Primary Dendritic Cells into Robust and Modular Artificial Antigen-Presenting Systems by Intracellular Hydrogelation." Adv Mater 33(30): e2101190.
Swygert, S. G., D. Lin, S. Portillo-Ledesma, P. Y. Lin, D. R. Hunt, C. F. Kao, T. Schlick, W. S. Noble and T. Tsukiyama (2021). "Local chromatin fiber folding represses transcription and loop extrusion in quiescent cells." Elife 10.
Wahyuningtyas, D., W. H. Chen, R. Y. He, Y. A. Huang, C. K. Tsao, Y. J. He, C. Y. Yu, P. C. Lu, Y. C. Chen, S. H. Wang, K. C. Ng, B. Po-Wen Chen, P. K. Wei, J. J. Shie, C. H. Kuo, Y. H. Sun and J. Jen-Tse Huang (2021). "Polyglutamine-Specific Gold Nanoparticle Complex Alleviates Mutant Huntingtin-Induced Toxicity." ACS Appl Mater Interfaces 13(51): 60894-60906.
Wang, Y. H., M. L. Jian, P. J. Chen, J. C. Tsou, L. P. Truong and Y. S. Wang (2021). "Ferritin Conjugates With Multiple Clickable Amino Acids Encoded by C-Terminal Engineered Pyrrolysyl-tRNA Synthetase." Front Chem 9: 779976.
Wu, K. C., K. F. Hua, Y. H. Yu, Y. H. Cheng, T. T. Cheng, Y. K. Huang, H. W. Chang and W. J. Chen (2021). "Antibacterial and Antibiofilm Activities of Novel Antimicrobial Peptides against Multidrug-Resistant Enterotoxigenic Escherichia Coli." Int J Mol Sci 22(8).
2020
Amartuvshin, O., C. H. Lin, S. C. Hsu, S. H. Kao, A. Chen, W. C. Tang, H. L. Chou, D. L. Chang, Y. Y. Hsu, B. S. Hsiao, E. Rastegari, K. Y. Lin, Y. T. Wang, C. K. Yao, G. C. Chen, B. C. Chen and H. J. Hsu (2020). "Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss." Aging Cell 19(8): e13191.
He, R. Y., X. M. Lai, C. S. Sun, T. S. Kung, J. Y. Hong, Y. S. Jheng, W. N. Liao, J. K. Chen, Y. F. Liao, P. H. Tu and J. J. Huang (2020). "Nanoscopic Insights of Amphiphilic Peptide against the Oligomer Assembly Process to Treat Huntington's Disease." Adv Sci (Weinh) 7(2): 1901165.
Hsu, H. M., Y. H. Huang, S. Aryal, H. W. Liu, C. Chen, S. H. Chen, C. H. Chu and J. H. Tai (2020). "Endomembrane Protein Trafficking Regulated by a TvCyP2 Cyclophilin in the Protozoan Parasite, Trichomonas vaginalis." Sci Rep 10(1): 1275.
Jiang, Y. F., H. L. Lin, L. J. Wang, T. Hsu and C. Y. Fu (2020). "Coordinated organization of mitochondrial lamellar cristae and gain of COX function during mitochondrial maturation in Drosophila." Mol Biol Cell 31(1): 18-26.
Liu, Y. M., M. Shahed-Al-Mahmud, X. Chen, T. H. Chen, K. S. Liao, J. M. Lo, Y. M. Wu, M. C. Ho, C. Y. Wu, C. H. Wong, J. T. Jan and C. Ma (2020). "A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2." Cell Rep 32(6): 108016.
Shih, Y. H., L. H. Tu, T. Y. Chang, K. Ganesan, W. W. Chang, P. S. Chang, Y. S. Fang, Y. T. Lin, L. W. Jin and Y. R. Chen (2020). "TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease." Nat Commun 11(1): 5950.
Sudhakar, J. N., H. H. Lu, H. Y. Chiang, C. S. Suen, M. J. Hwang, S. Y. Wu, C. N. Shen, Y. M. Chang, F. A. Li, F. T. Liu and J. W. Shui (2020). "Lumenal Galectin-9-Lamp2 interaction regulates lysosome and autophagy to prevent pathogenesis in the intestine and pancreas." Nat Commun 11(1): 4286.
Wang, L. J., T. Hsu, H. L. Lin and C. Y. Fu (2020). "Drosophila MICOS knockdown impairs mitochondrial structure and function and promotes mitophagy in muscle tissue." Biol Open 9(12).
Yang, M. T., T. F. Kuo, K. F. Chung, Y. C. Liang, C. W. Yang, C. Y. Lin, C. S. Feng, Z. W. Chen, T. H. Lee, C. L. Hsiao and W. C. Yang (2020). "Authentication, phytochemical characterization and anti-bacterial activity of twoArtemisiaspecies." Food Chem 333: 127458.
2019
Hong, M. H., W. H. Lin, I. C. Weng, Y. H. Hung, H. L. Chen, H. Y. Chen, P. Chen, C. H. Lin, W. Y. Yang and F. T. Liu (2019). "Intracellular galectins control cellular responses commensurate with cell surface carbohydrate composition." Glycobiology 30(1): 49-57.
Huang, C. M., S. Y. Lyu, K. H. Lin, C. L. Chen, M. H. Chen, H. W. Shih, N. S. Hsu, I. W. Lo, Y. L. Wang, Y. S. Li, C. J. Wu and T. L. Li (2019). "Teicoplanin Reprogrammed with the N-Acyl-Glucosamine Pharmacophore at the Penultimate Residue of Aglycone Acquires Broad-Spectrum Antimicrobial Activities Effectively Killing Gram-Positive and -Negative Pathogens." ACS Infect Dis 5(3): 430-442.
Lin, J. C., C. Y. Chien, C. L. Lin, B. Y. Yao, Y. I. Chen, Y. H. Liu, Z. S. Fang, J. Y. Chen, W. Y. Chen, N. N. Lee, H. W. Chen and C. J. Hu (2019). "Intracellular hydrogelation preserves fluid and functional cell membrane interfaces for biological interactions." Nat Commun 10(1): 1057.
Shen, H. C., Y. H. Chen, Y. S. Lin, B. K. Chu, C. S. Liang, C. C. Yang and R. P. Chen (2019). "Segments in the Amyloid Core that Distinguish Hamster from Mouse Prion Fibrils." Neurochem Res 44(6): 1399-1409.
Siew, J. J., H. M. Chen, H. Y. Chen, H. L. Chen, C. M. Chen, B. W. Soong, Y. R. Wu, C. P. Chang, Y. C. Chan, C. H. Lin, F. T. Liu and Y. Chern (2019). "Galectin-3 is required for the microglia-mediated brain inflammation in a model of Huntington's disease." Nat Commun 10(1): 3473.
Tsai, J. J., W. B. Hsu, J. H. Liu, C. W. Chang and T. K. Tang (2019). "CEP120 interacts with C2CD3 and Talpid3 and is required for centriole appendage assembly and ciliogenesis." Sci Rep 9(1): 6037.
2018
Glal, D., J. N. Sudhakar, H. H. Lu, M. C. Liu, H. Y. Chiang, Y. C. Liu, C. F. Cheng and J. W. Shui (2018). "ATF3 Sustains IL-22-Induced STAT3 Phosphorylation to Maintain Mucosal Immunity Through Inhibiting Phosphatases." Front Immunol 9: 2522.
Lee, M. C., W. C. Yu, Y. H. Shih, C. Y. Chen, Z. H. Guo, S. J. Huang, J. C. C. Chan and Y. R. Chen (2018). "Zinc ion rapidly induces toxic, off-pathway amyloid-β oligomers distinct from amyloid-β derived diffusible ligands in Alzheimer's disease." Sci Rep 8(1): 4772.
Syu, Y. W., H. W. Lai, C. L. Jiang, H. Y. Tsai, C. C. Lin and Y. C. Lee (2018). "GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function." Hum Mol Genet 27(2): 307-321.
Tu, L. H., N. H. Tseng, Y. R. Tsai, T. W. Lin, Y. W. Lo, J. L. Charng, H. T. Hsu, Y. S. Chen, R. J. Chen, Y. T. Wu, Y. T. Chan, C. S. Chen, J. M. Fang and Y. R. Chen (2018). "Rationally designed divalent caffeic amides inhibit amyloid-β fibrillization, induce fibril dissociation, and ameliorate cytotoxicity." Eur J Med Chem 158: 393-404.
Wu, C. T., H. Y. Chen and T. K. Tang (2018). "Myosin-Va is required for preciliary vesicle transportation to the mother centriole during ciliogenesis." Nat Cell Biol 20(2): 175-185.
2017
Chang, H. F., S. L. Wang and K. C. Yeh (2017). "Effect of Gallium Exposure in Arabidopsis thaliana is Similar to Aluminum Stress." Environ Sci Technol 51(3): 1241-1248.
Cheng, Y. S., Z. T. Chen, T. Y. Liao, C. Lin, H. C. Shen, Y. H. Wang, C. W. Chang, R. S. Liu, R. P. Chen and P. H. Tu (2017). "An intranasally delivered peptide drug ameliorates cognitive decline in Alzheimer transgenic mice." EMBO Mol Med 9(5): 703-715.
Hu, C. J., C. Y. Chien, M. T. Liu, Z. S. Fang, S. Y. Chang, R. H. Juang, S. C. Chang and H. W. Chen (2017). "Multi-antigen avian influenza a (H7N9) virus-like particles: particulate characterizations and immunogenicity evaluation in murine and avian models." BMC Biotechnol 17(1): 2.
Jiang, Y. F., H. L. Lin and C. Y. Fu (2017). "3D Mitochondrial Ultrastructure of Drosophila Indirect Flight Muscle Revealed by Serial-section Electron Tomography." J Vis Exp(130).
Jiang, Y. F., S. S. Lin, J. M. Chen, H. Z. Tsai, T. S. Hsieh and C. Y. Fu (2017). "Electron tomographic analysis reveals ultrastructural features of mitochondrial cristae architecture which reflect energetic state and aging." Sci Rep 7: 45474.
Lin, B. L., C. Y. Chen, C. H. Huang, T. P. Ko, C. H. Chiang, K. F. Lin, Y. C. Chang, P. Y. Lin, H. G. Tsai and A. H. Wang (2017). "The Arginine Pairs and C-Termini of the Sso7c4 from Sulfolobus solfataricus Participate in Binding and Bending DNA." PLoS One 12(1): e0169627.
Lin, T. W., C. F. Chang, Y. J. Chang, Y. H. Liao, H. M. Yu and Y. R. Chen (2017). "Alzheimer's amyloid-β A2T variant and its N-terminal peptides inhibit amyloid-β fibrillization and rescue the induced cytotoxicity." PLoS One 12(3): e0174561.
Yang, J. R., C. Y. Cheng, C. Y. Chen, C. H. Lin, C. Y. Kuo, H. Y. Huang, F. T. Wu, Y. C. Yang, C. Y. Wu, M. T. Liu and P. W. Hsiao (2017). "A virus-like particle vaccination strategy expands its tolerance to H3N2 antigenic drift by enhancing neutralizing antibodies against hemagglutinin stalk." Antiviral Res 140: 62-75.
2016
Chang, Y. J., U. S. Jeng, Y. L. Chiang, I. S. Hwang and Y. R. Chen (2016). "The Glycine-Alanine Dipeptide Repeat from C9orf72 Hexanucleotide Expansions Forms Toxic Amyloids Possessing Cell-to-Cell Transmission Properties." J Biol Chem 291(10): 4903-4911.
Chang, Y. J., N. H. Linh, Y. H. Shih, H. M. Yu, M. S. Li and Y. R. Chen (2016). "Alzheimer's Amyloid-β Sequesters Caspase-3 in Vitro via Its C-Terminal Tail." ACS Chem Neurosci 7(8): 1097-1106.
Chen, H. W., C. Y. Huang, S. Y. Lin, Z. S. Fang, C. H. Hsu, J. C. Lin, Y. I. Chen, B. Y. Yao and C. M. Hu (2016). "Synthetic virus-like particles prepared via protein corona formation enable effective vaccination in an avian model of coronavirus infection." Biomaterials 106: 111-118.
Chen, H. Y., D. M. Chiang, Z. J. Lin, C. C. Hsieh, G. C. Yin, I. C. Weng, P. Guttmann, S. Werner, K. Henzler, G. Schneider, L. J. Lai and F. T. Liu (2016). "Nanoimaging granule dynamics and subcellular structures in activated mast cells using soft X-ray tomography." Sci Rep 6: 34879.
Hou, S. C., H. S. Chen, H. W. Lin, W. T. Chao, Y. S. Chen, C. Y. Fu, C. M. Yu, K. F. Huang, A. H. Wang and A. S. Yang (2016). "High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries." Sci Rep 6: 31878.
Juo, L. Y., W. C. Liao, Y. L. Shih, B. Y. Yang, A. B. Liu and Y. T. Yan (2016). "HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles." J Cell Sci 129(8): 1661-1670.
Liu, C. C., Y. C. Lin, Y. H. Chen, C. M. Chen, L. Y. Pang, H. A. Chen, P. R. Wu, M. Y. Lin, S. T. Jiang, T. F. Tsai and R. H. Chen (2016). "Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination." Mol Cell 61(1): 84-97.
Siaw, G. E., I. F. Liu, P. Y. Lin, M. D. Been and T. S. Hsieh (2016). "DNA and RNA topoisomerase activities of Top3β are promoted by mediator protein Tudor domain-containing protein 3." Proc Natl Acad Sci U S A 113(38): E5544-5551.
2015
Liao, Y. H. and Y. R. Chen (2015). "A novel method for expression and purification of authentic amyloid-β with and without (15)N labels." Protein Expr Purif 113: 63-71.
Wu, C. Y., Y. W. Lin, C. H. Kuo, W. H. Liu, H. F. Tai, C. H. Pan, Y. T. Chen, P. W. Hsiao, C. H. Chan, C. C. Chang, C. C. Liu, Y. H. Chow and J. R. Chen (2015). "Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse." PLoS One 10(8): e0136420.
2014
Fang, Y. S., K. J. Tsai, Y. J. Chang, P. Kao, R. Woods, P. H. Kuo, C. C. Wu, J. Y. Liao, S. C. Chou, V. Lin, L. W. Jin, H. S. Yuan, I. H. Cheng, P. H. Tu and Y. R. Chen (2014). "Full-length TDP-43 forms toxic amyloid oligomers that are present in frontotemporal lobar dementia-TDP patients." Nat Commun 5: 4824.
Lin, C., E. H. Chen, L. Y. Lee, R. L. Hsu, F. Y. Luh, L. L. Yang, C. F. Chou, L. D. Huang, C. C. Lin and R. P. Chen (2014). "Comparison of the anti-amyloidogenic effect of O-mannosylation, O-galactosylation, and O-GalNAc glycosylation." Carbohydr Res 387: 46-53.
Pan, C. Y., J. C. Chen, J. F. Sheen, T. L. Lin and J. Y. Chen (2014). "Epinecidin-1 has immunomodulatory effects, facilitating its therapeutic use in a mouse model of Pseudomonas aeruginosa sepsis." Antimicrob Agents Chemother 58(8): 4264-4274.
Wu, C. Y., C. Y. Chang, H. H. Ma, C. W. Wang, Y. T. Chen, P. W. Hsiao, C. C. Chang, C. H. Chan, C. C. Liu and J. R. Chen (2014). "Squalene-adjuvanted H7N9 virus vaccine induces robust humoral immune response against H7N9 and H7N7 viruses." Vaccine 32(35): 4485-4494.
2013
Ariesandi, W., C. F. Chang, T. E. Chen and Y. R. Chen (2013). "Temperature-dependent structural changes of Parkinson's alpha-synuclein reveal the role of pre-existing oligomers in alpha-synuclein fibrillization." PLoS One 8(1): e53487.
Chatterjee, B., C. Y. Lee, C. Lin, E. H. Chen, C. L. Huang, C. C. Yang and R. P. Chen (2013). "Amyloid core formed of full-length recombinant mouse prion protein involves sequence 127-143 but not sequence 107-126." PLoS One 8(7): e67967.
Chen, R. J., W. W. Chang, Y. C. Lin, P. L. Cheng and Y. R. Chen (2013). "Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway." ACS Chem Neurosci 4(9): 1287-1296.
Chuang, C. C., T. Y. Liao, E. H. Chen and R. P. Chen (2013). "How do amino acid substitutions affect the amyloidogenic properties and seeding efficiency of prion peptides." Amino Acids 45(4): 785-796.
Viet, M. H., C. Y. Chen, C. K. Hu, Y. R. Chen and M. S. Li (2013). "Discovery of dihydrochalcone as potential lead for Alzheimer's disease: in silico and in vitro study." PLoS One 8(11): e79151.
Yu, X., L. Jin, J. Jih, C. Shih and Z. H. Zhou (2013). "3.5Å cryoEM structure of hepatitis B virus core assembled from full-length core protein." PLoS One 8(9): e69729.
2012
Chang, T. W., Y. M. Lin, C. F. Wang and Y. D. Liao (2012). "Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides." J Biol Chem 287(1): 418-428.
Chen, W. T., C. J. Hong, Y. T. Lin, W. H. Chang, H. T. Huang, J. Y. Liao, Y. J. Chang, Y. F. Hsieh, C. Y. Cheng, H. C. Liu, Y. R. Chen and I. H. Cheng (2012). "Amyloid-beta (Aβ) D7H mutation increases oligomeric Aβ42 and alters properties of Aβ-zinc/copper assemblies." PLoS One 7(4): e35807.
Chen, Y. C., Y. F. Lu, I. C. Li and S. P. Hwang (2012). "Zebrafish Agr2 is required for terminal differentiation of intestinal goblet cells." PLoS One 7(4): e34408.
Liao, Y. H., Y. J. Chang, Y. Yoshiike, Y. C. Chang and Y. R. Chen (2012). "Negatively charged gold nanoparticles inhibit Alzheimer's amyloid-β fibrillization, induce fibril dissociation, and mitigate neurotoxicity." Small 8(23): 3631-3639.
Wu, C. Y., Y. C. Yeh, J. T. Chan, Y. C. Yang, J. R. Yang, M. T. Liu, H. S. Wu and P. W. Hsiao (2012). "A VLP vaccine induces broad-spectrum cross-protective antibody immunity against H5N1 and H1N1 subtypes of influenza A virus." PLoS One 7(8): e42363.